Shire Test Prep

Improving and Protecting the Ocular Surface


The abrasion healed within 3 days after removal of the amniotic ring. In the next 3 months, the patient’s vision improved significantly, to 20/70 OD and 20/100 OS, respectively.

The patient was continued on a regimen of gel artificial tears and preservative-free artificial tears. However, about 7 months after her first episode of corneal abrasion, a 2- x 2.5-mm central epithelial defect recurred in the left eye with reduced vision, leaving her 20/200 OD and 20/400 OS. After insertion of a bandage lens and then another amniotic ring, the epithelial defect healed in 2 weeks and the vision of the left eye improved to 20/70.

She then continued on the preservative-free artificial tear regimen and topical cyclosporine. After 5 months, she was still unable to read (she was 20/200 OD and 20/100 OS), and moderate to severe superficial punctuate keratopathy continued to exist in both eyes. By then she had begun to have problems putting drops in the eyes so often.

I suggested LACRISERT® (hydroxypropyl cellulose ophthalmic insert) to the patient. Why do you think I suggested LACRISERT for this patient?

a. Once-daily dosing
b. Continuous lubrication and protection
c. Free of preservatives
d. All of the above

Indications and Usage

LACRISERT® (hydroxypropyl cellulose ophthalmic insert) is indicated in patients with moderate to severe dry eye syndromes, including keratoconjunctivitis sicca. LACRISERT is indicated especially in patients who remain symptomatic after an adequate trial of therapy with artificial tear solutions. LACRISERT is also indicated for patients with exposure keratitis, decreased corneal sensitivity, and recurrent corneal erosions.

Important Safety Information

  • LACRISERT® (hydroxypropyl cellulose ophthalmic insert) is contraindicated in patients who are hypersensitive to hydroxypropyl cellulose.
  • Instructions for inserting and removing LACRISERT should be carefully followed.
  • If improperly placed, LACRISERT may result in corneal abrasion. Because LACRISERT may cause transient blurred vision, patients should be instructed to exercise caution when driving or operating machinery.
  • The following adverse reactions have been reported, but were in most instances mild and temporary: transient blurring of vision, ocular discomfort or irritation, matting or stickiness of eyelashes, photophobia, hypersensitivity, eyelid edema, and hyperemia.

Please see full Prescribing Information for LACRISERT® (hydroxypropyl cellulose ophthalmic insert).



Paul Karpecki, OD, FAAO

Paul Karpecki, OD, FAAO, works in Corneal Services and is clinical research director at the Koffler Vision Group in Lexington, KY. He is a consultant for Bausch + Lomb and Bio-Tissue Inc.

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